Amygdala Kindling in the WAG/Rij Rat Model of Absence Epilepsy
نویسندگان
چکیده
منابع مشابه
Establishment and evaluation of rat epilepsy model by basolateral amygdala kindling
This study aims to establish a rat epileptic model by basolateral amygdala (BLA) kindling and evaluate its feasibility. Forty male rats were randomly divided into blank group (5 rats; no electrode insertion), sham-operated group (5 rats; the electrodes were inserted in BLA, without electrical stimulation) and kindling group (30 rats; the electrodes were inserted in BLA; the electrical stimulati...
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Histochemical and autoradiographic techniques were used to study mossy fiber sprouting which occurs in the hippocampus of kindled rats. In rats kindled by daily stimulation of amygdala or entorhinal cortex, the mossy fibers sprout to innervate the supragranular zone of fascia dentata; this synaptic reorganization was associated with a significant increase in the density of high-affinity kainic ...
متن کاملPharmacodynamic and pharmacokinetic interactions of perampanel and other antiepileptic drugs in a rat amygdala kindling model
PURPOSE This study explored the pharmacodynamic and pharmacokinetic effects of combining perampanel (PER) with commonly co-administered AEDs. METHOD A strong stimulus intensity (three-fold higher than after-discharge threshold) was used to elicit drug-resistant seizures in a rat amygdala kindling model. Vehicle, low-dose PER (0.75 mg/kg), or high-dose PER (1.5mg/kg), in combination with vehic...
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Female Wistar rats were implanted with electrodes in the right amygdala, and initial--pre-kindling--afterdischarge thresholds (ADT's) were determined 1, 2, 4, and 8 weeks after electrode implantation. Pre-kindling ADT's were highest 1 week after implantation, lower at 2 weeks, and lowest at 4 weeks. This drop in non-stimulated thresholds had largely disappeared by 8 weeks post-implantation. Hal...
متن کاملEffect of minocycline on amygdala kindling acquisition in rats
Introduction: Minocycline is a derivative of tetracycline that has anti-inflammatory, antiappoptic, antioxidant and neuroprotective effects. Since there is a relationship between cell death and seizure, the aim of this study was to examine the role of minocycline in development of amygdala kindling in Wistar rats. Methods: In this study, 21 rats were divided into three groups. After sterotax...
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ژورنال
عنوان ژورنال: Epilepsia
سال: 2006
ISSN: 0013-9580,1528-1167
DOI: 10.1111/j.1528-1167.2006.00367.x